Since subcutaneous adipocytes typically display lower densities of GH receptors than visceral adipocytes, they may not respond as well to GH-induced or Frag 176-191-mediated lipolysis, possibly resulting in differential regional adipose mobilization
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Plasma half-life is brief (2638 minutes in human studies), driven primarily by enzymatic cleavage at specific peptide bonds and rapid receptor-mediated endocytosis following GHRH receptor binding in the anterior pituitary
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