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Furthermore, heme can drive TNF-- and ROS-mediated necroptosis [225], heme oxygenase 1-dependent ferroptosis [226], and NLRP3 inflammasome-associated pyroptosis [227], which are highly proinflammatory RCDs

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Consequently, the modification and transformation of NADs and the development of efficient, safe, and targeted delivery systems have become the primary focus of research and development on NADs