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Importantly, 40%60% of patients present with allergic multimorbidity, particularly concurrent allergic rhinitis and atopic dermatitis, which synergistically exacerbate disease progression and substantially impair quality of life metrics ( The gut microbiota, comprising a complex ecosystem of commensal microorganisms, exerts systemic immunomodulatory effects through bidirectional gut-lung axis communication

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Both showed benefit, but results were not broken down by medication

While not considered a direct target of disease as in NMOSD, astrocytes retain central roles in other forms of demyelination

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