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Another small, randomized, double-blind trial in 93 individuals with low vitamin D status found no additional benefit of B-vitamin supplementation (50 mg/day of vitamin B6, 0.5 mg/day of folic acid, and 0.5 mg/day of vitamin B 12 ) on markers of bone health over a one-year period beyond that associated with vitamin D and calcium supplementation

Specifically, many of its ingredients are listed as part of proprietary blends that obscure how much (or, really, how little) is in each serving, and some potential side effects arent mentioned by Onnit

Vitamin B12 injection is the most easily absorbable form

Neuropathy and nerve regeneration The strongest evidence for ARA-290 comes from studies on small fiber neuropathy