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CGRP released from cutaneous trigeminal nerve fibers and acts on surrounding Schwann cells, perpetuating cutaneous allodynia through a cyclic AMP-dependent mechanism that generates NO in endosomes (31)

Low dose NAC was chosen in this study because of its safe side effect profile, however, it is possible that these lower doses prevented therapeutic levels of NAC thereby limiting the beneficial effects

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for many women, the hormonal and physical changes associated with their menstrual cycles can significantly impact their quality of life