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10.1016/j.tox.2020.152598 97 SquireJ

Notably, thyroid hormones may facilitate augmented carnitine synthesis in the liver by increasing -butyrobetaine hydroxylase (BBD) activity and gene expression, which may constitute a feedback regulatory loop between thyroid hormones and carnitine [80]

In addition, since multiple factors underlie the complex pathogenesis of Hg toxicity including genetic and environmental factors, their interactions could also be contributing to the associations found in our study

[22] Anti-cancer treatment [edit] SAM has recently been shown to play a role in epigenetic regulation

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