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Upon activation, mTOR phosphorylates downstream targets, including eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and S6K1, to promote protein translation (69,85)

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Prof Alexander Miras, an obesity expert at Ulster University who was not involved in the work, described the findings as very important, noting that while GLP-1s had been associated with improved functionality meaning it was easier to carry out everyday activities they had also been associated with a loss in muscle mass and strength

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