Proposed mechanisms of Tesamorelin: Activates GHRH receptors Increases endogenous GH release Elevates IGF-1 production Promotes lipolysis Reduces visceral adipose tissue Why Tesamorelin is unique: Unlike most weight-loss therapies, Tesamorelin appears particularly effective at reducing visceral fat the deep abdominal fat surrounding internal organs that is strongly associated with insulin resistance, cardiovascular disease, and metabolic syndrome
Compared to other GHRH analogs, tesamorelin is particularly notable for its effect on visceral adipose tissue
Remarkable changes from baseline to week 32 were also seen in average glucose levels measured by continuous glucose measuring, as well as fasting plasma glucose
Twenty-four-hour urinary output was reduced by 943 mL (95% CI: 1473, 413
Its action as a "triple G" or GGG tri-agonist means it acts on GLP-1, GIP, and GCG receptors, potentially leading to more substantial weight loss compared to dual agonists such as tirzepatide