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Description

Proposed mechanisms of Tesamorelin: Activates GHRH receptors Increases endogenous GH release Elevates IGF-1 production Promotes lipolysis Reduces visceral adipose tissue Why Tesamorelin is unique: Unlike most weight-loss therapies, Tesamorelin appears particularly effective at reducing visceral fat the deep abdominal fat surrounding internal organs that is strongly associated with insulin resistance, cardiovascular disease, and metabolic syndrome

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Compared to other GHRH analogs, tesamorelin is particularly notable for its effect on visceral adipose tissue

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Remarkable changes from baseline to week 32 were also seen in average glucose levels measured by continuous glucose measuring, as well as fasting plasma glucose

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Twenty-four-hour urinary output was reduced by 943 mL (95% CI: 1473, 413

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Its action as a "triple G" or GGG tri-agonist means it acts on GLP-1, GIP, and GCG receptors, potentially leading to more substantial weight loss compared to dual agonists such as tirzepatide

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