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At the molecular level, morroniside upregulated the gene expression of IL-10 and -endorphin in the spinal cord of neuropathic rats as well as in primary cultured microglia [74]

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SXD reported ZO-1/occludin upregulation and improvement in permeability markers like DAO, ET, D-LA, and Zonulin, alongside restored Th17/Treg balance (Sun et al., 2025)

The histological analysis of the biopsies of those patients revealed structural alteration in the dermis, as weight loss possibly affects the density of collagen and elastic fibers [7, 10,11,12]

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