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Although randomised clinical trials (RCTs) are essential in gaining regulatory approval, data from non-interventional studies provide insights into how medication is used and performs in routine clinical practice

Body weight, metabolic status, and concurrent medicationsparticularly those affecting gastrointestinal motility (such as opioids or anticholinergics) or glucose metabolismcan modify both the intensity and duration of adverse effects

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Endocrine (2020) 68:51825

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