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In another THCA transcriptome data ( RRM2 gene in the whole biological behavior of tumors, we performed a pan-cancer analysis by the combination of TCGA and GTEx data, which showed that RRM2 was generally highly expressed in tumors of epithelial origin, such as THCA, esophageal carcinoma, and breast carcinoma, suggesting that its pro-carcinogenic mechanism is conserved by the cancer species

Loprinzi et al., 2020

Agmatine protects against intracerebroventricular streptozotocin-induced water maze memory deficit, hippocampal apoptosis and Akt/GSK3 signaling disruption