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The ACHIEVE-3 trial provided the first head-to-head comparison, showing orforglipron superior to oral semaglutide for both glycemic control and weight loss in type 2 diabetes

The sublingual area has the highest concentration of blood vessels in the oral cavity

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Common timeline: First 12 weeks: Side effects may still occur Weeks 35: Side effects typically resolve After 5 weeks: Medication is mostly cleared Side effects usually disappear If side effects persist beyond this period, medical evaluation may be helpful