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AOD 9604, because it works specifically on adipose tissue through lipolytic pathways, theoretically targets fat preferentially

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At 30 days, it dropped to 0.824%

In a cellular model of CF, ASOs were designed to target the inhibitory secondary mRNA structures in the uORF of the 5 UTR on the CFTR mRNA transcripteffectively increasing both the expression and function of CFTR [88]

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