Upon UVA radiation, melanocytes emit extracellular vesicles laden with diverse cellular components notably miR-21 mediating the signal transduction in the keratinocytes and leading to their increased proliferation and heightened anti-apoptotic mechanisms, which links to the development of skin cancer [154].UVB irradiation could reduce the expression of miR-137 that could inhibit the tumorigenic phenotype in human epidermal melanocyte cell and increase the expression of miR-29a-3p and miR-183-5p that could downregulate the phosphatase and tensin homolog (PTEN) involved in the metastatic progression of cSCC [155,156,157]
Maitra, I., Serbinova, E., Trischler, H., and Packer, L
the atmosphere in the vessel can be, for example, sterile clean air or sterile clean nitrogen gas
Tlenek azotu rozszerza naczynia krwionone i poprawia mikrokrenie
doi: 10.1002/adhm.202203172 60 FeitorJFBrazacaLCLimaAMFerreiraVGKassabGBagnatoVSet al