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Thus, loss of STAT1 in tumor cells abrogates interferon gamma-mediated downregulation of SLC7A11 while reversing RSL3-induced lipid peroxidation and ferroptosis [156]

This enzyme specifically catalyzes the reduction of lipid peroxides within cell membranes to their corresponding non-toxic lipid alcohols, thereby effectively blocking the propagation of lipid peroxidation chain reactions

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170 Similarly, in myoblasts, knocking down ZIP8 also hampers myotube formation by causing a significant reduction in cellular manganese, iron, zinc, and calcium levels, leading to decreased differentiation and proliferation of myoblasts 171 (Fig