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Studies demonstrate FOXO4-DRI achieves comparable renal function restoration to genetic clearance of senescent cells using the p16-3MR suicide gene system, confirming that therapeutic effects result specifically from senescent cell elimination rather than off-target actions

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Exenatide, another GLP-1 analog, has also been shown to provide cardioprotection via similar mechanisms [57]

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But the scavenging superoxide anion radical capacity of ToEGCG was significantly higher than EGCG

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AlvarezJAChowdhuryRJonesDPMartinGSBrighamKLBinongoJNet al

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10.1210/jcem-63-2-492 45 NauckM

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