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Safety Profile as a Reflection of Mechanism Each major side effect maps directly to a specific receptor-mediated pathway
The FLOW (Evaluate Renal F unction with Semag l utide O nce W eekly) study is a double-blind, randomised, placebo-controlled international trial comprising 3,533 patients, with a median follow-up period of 3.4 years
no hierarchy is implied) Option (Evidence Strength: Grades B, B, C, and B) Clinicians should counsel patients who are considering pentosan polysulfate about the potential risk for macular damage and vision-related injuries
Published Phase 2 data shows: Dose Group Discontinuation Due to AE Placebo 0% 1 mg 2.9% 4 mg (escalated) 5.7% 8 mg (escalated) 5.0% 12 mg (escalated) 8.3% For context, discontinuation rates in semaglutide 2.4 mg trials (STEP program) were approximately 7%, and tirzepatide 15 mg trials (SURMOUNT) reported approximately 6-7%
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