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Interestingly, decaffeinated coffee and nicotine-free tobacco were neuroprotective in a Drosophila model of PD, but, the neuroprotection depended on the cytoprotective transcription factor nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and cafestol (an activator) (Trinh et al., 2010)

They are complementary rather than competitive, which is why the recommended protocol rotates them across sessions

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Additionally, there has been significant growth and development in technology including Meibography providing the ability to image Meibomian glands, and a plethora of FDA approved medications and treatment modalities including, BlephEx, LipiFlow, TearCare, iLux, autologous serum, amniotic membranes, Meibomian gland probing, and Exosome therapy