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A 2025 peer-reviewed reply in Pharmaceuticals by Jzwiak and colleagues explicitly flagged BPC-157s pro-angiogenic and nitric oxide-related activities as warranting serious investigation regarding neurodegenerative disease

30(13): p

Cartilage itself is not innervated, but nociceptors are present in surrounding tissues, such as the synovium and joint capsule, subchondral bone, periosteum, meniscus, and ligaments 39