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Research uses MT-II alongside subtype-selective agonists and antagonists to establish how the combined activation of multiple melanocortin receptor subtypes simultaneously produces a different biological profile than selective activation of any single subtype and characterising the synergistic, additive, or redundant relationships between MC1R, MC3R, and MC4R-mediated biology

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S-100 protein is frequently used to highlight the spindled, more neural-appearing melanocytes, whereas HMB-45 is used to identify the round cells

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