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[DOI] [Google Scholar] 143.Mikus D., Sikiric P., Seiwerth S., Petricevic A., Aralica G., Druzijancic N., Rucman R., Petek M., Pigac B., Perovic D., et al

If conservative measures are insufficient and cold intolerance significantly impacts quality of life, discuss with your healthcare provider whether medication adjustment, additional metabolic assessment, or consultation with an endocrinologist might be beneficial

Several phytochemicals, including berberine and other isoquinoline alkaloids, inhibit the assembly and activation of NLRP3, reducing mature pro-inflammatory cytokine release and mitigating neuroinflammation and neuronal loss in PD models ( Beyond immunomodulation, many plant phytoconstituents exert antioxidant and mitochondrial protective effects that are crucial in neurodegeneration

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