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The absorption of concomitant oral medications may be reduced or delayed when tirzepatide therapy is initiated

VPA administration in pregnant ICR mice on E8 caused neural tube defects, which were prevented by oral folic acid administration prior to the VPA injection (110)

Data was graphed after normalizing each insulin time course by dividing by the secretion rate at each time point by the rate obtained in the presence of 20 mM glucose prior to the addition of test compounds