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2.6 -arrestin activation assay The assay was adapted from a previous description (Oishi et al ., 2019)
Abbreviations MS: Melanotic schwannoma PMS: Psammomatous melanotic schwannomas CT: Computer tomography CDC: Centers for Disease Control and Prevention BMI: Body mass index MRI: Magnetic resonance imaging COVID-19: Coronavirus disease 2019 RK: Right kidney IVC: Inferior vena cava Tu: Tumor RRV: Right renal vein Adr: Adrenal gland HPF: High-power field HMB45: Human melanoma black 45 STIR: Short tau inversion recovery References Vallat-Decouvelaere AV, Wassef M, Lot G, Catala M, Moussalam M, Caruel N, et al
ECL1, ECL3 and ICL3 were not modelled as the density was less well resolved indicative of higher flexibility within these domains
This novel approach to melanocortin receptor selectivity for weight loss was informed by our previous work demonstrating that co-administration of an MC4R-selective agonist and an MC3R-selective agonist caused a greater reduction in food intake and body weight in DIO NHPs than administration of either compound alone, yielding 7.8% weight loss after 36 days (25)
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