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Clinical studies most often report mild side effects, including nausea, vomiting, diarrhea, heartburn, gas, headache, and general digestive discomfort.27 A 2021 safety review of high-dose NAC in chronic respiratory diseases found that oral doses between 600mg and 3,000mg daily were generally well tolerated, with gastrointestinal symptoms reported but not consistently more often than placebo.35 That doesnt mean NAC is risk-free

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Oncogenic KRAS regulates amino acid homeostasis and asparagine biosynthesis via ATF4 and alters sensitivity to L-asparaginase