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That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route

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When a source says one is stronger than the other, it is lining up REDEFINE 1s roughly 20.4% at 68 weeks against SURMOUNT-1s roughly 20.9% at 72 weeks two numbers from two different trials, in different populations, over different durations, against different comparators

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