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Conclusion Demonstration of effective and safe lowering of plasma p-tau181 with SAMe in this phase II trial would pave the way for an exciting field of translational research and a larger phase III trial

Omega-3 DPA protected neurons from Neuroinflammation by balancing microglia M1/M2 polarizations through inhibiting NF-kappaB/MAPK p38 signaling and activating neuron-BDNF-PI3K/AKT pathways

Extending doses to every other week has not been studied in major trials and may reduce appetite suppression and weight loss effectiveness

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