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It can be risky and is invasive

Although the exact signaling pathways are not fully understood, it is often suggested that the pro-opiomelanocortin (POMC)-derived melanocortin peptides, including compounds analogous to a-melanocyte-stimulating hormone (a-MSH), may influence neuronal structures by increasing the number and length of neurites and potentially promoting nerve sprouting in damaged regions

A successful intervention strategy must be layered, addressing both upstream triggers and downstream consequences

You also add a new risk: dosing is less controlled, and the nasal lining can react

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