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the highest expression levels are in the lung, spleen, kidney, liver, and myeloid cell lineages, particularly neutrophils, mast cells, monocytes, macrophages, and their precursors ( Figure 3 ) ( Figure 3 Crystal structures of DPP1 in complex with small molecule inhibitors have provided insight into the substrate-binding pockets ( 2.2 Extracellular DPP1 Upon neutrophil activation, mature DPP1 and other granule-associated proteases are secreted into the extracellular milieu

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