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Originally developed to manage type 2 diabetes, semaglutide functions as a glucagon-like peptide-1 (GLP-1) receptor agonist, which plays a crucial role in appetite regulation and metabolic health

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Thirdly, given that insulin use has been associated with adverse cardiovascular effects, we did a separate analysis in which we excluded patients who had used insulin at study cohort entry and censored on insulin use during follow-up

Preserving lean muscle is essential for maintaining metabolic rate