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doi:10.1002/14651858.CD012906.pub2

[143] FosB is the most significant biomolecular mechanism in addiction because FosB overexpression (i.e., an abnormally high level of gene expression which produces a pronounced gene-related phenotype) in the D1-type medium spiny neurons in the nucleus accumbens is necessary and sufficient [note 13] for many of the neural adaptations and regulates multiple behavioral effects (e.g., reward sensitization and escalating drug self-administration) involved in addiction

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Jick H, Jick SS, Gurewich V, Myers MW, Vasilakis C

An assessment of womens knowledge of the menstrual cycle and the influence of diet and adherence to dietary patterns on the alleviation or exacerbation of menstrual distress