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2.3 Accumulation and transfer of metabolic intermediates Tumour growth not only requires abundant lactates produced by glycolysis, but also requires pathways such as the pentose phosphate pathway (PPP), serine pathway, and hexosamine biosynthesis pathway, which provide macromolecular substrates for the phospholipids, nucleotides and amino acids required for cancer cell proliferation

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A feedback inhibition by cysteine decreased SERAT1;1 and -3;1 activity but appeared to have no impact on the three other SERAT isoforms (Figure 2 and Supplementary Table 2

Subgroup analyses by sex and age showed consistent results