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doi: 10.1136/heartjnl-2015-308826

The four components dont all point to the same mechanism

Mechanism of cisplatin-induced cytotoxicity is correlated to impaired metabolism due to mitochondrial ROS generation

In addition, platelet-derived IgG-containing microparticles, mitochondria, mtDNA, and cytokines are targets of autoantibodies to form immune complexes in SLE

The final step of BH 4 synthesis actually involves three distinct steps all of which are catalyzed by the NADPH-dependent enzyme, sepiapterin reductase (SR)