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These two also have a sparing effect upon each other

Complicating the matter, administration of ghrelin still leads to cross-desensitization of dopamine-induced Ca 2+ mobilization, and while ghrelin antagonism also reduces this mobilization, it is possible that concurrent cross-sensitization may also occur, which may possibly carry beyond the timeframe of bioavailability of such an antagonist

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doi: 10.1016/j.dld.2019.09.002 48

Category 2 is the designation reserved for substances the agency has identified as presenting significant safety concerns, and which may not be compounded absent an authorizing regulation