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Some people report having received medical advice to eat a junk diet to combat symptoms, the lack of fibre in this diet may well improve some peoples symptoms in the short term, however long term implications for health of the digestive system and general health of the patient are a concern for this method

IGF-I signaling is important in skeletal muscle maintenance and repair IGF-I can reverse various muscle wasting conditions in experimental models The potential therapeutic effect of novel IGF-I formulations and biodegradable IGF-I variants must be explored in clinical trials Acknowledgements This work was supported by the project for the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)

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These symptoms are associated with the progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta (SNpc) and the presence of lewy bodies, composed of -syn aggregates [114, 115]

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