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The cathepsins released from damaged lysosomes play important roles in the process of pyroptosis

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Besides ASCT2 for glutamine transportation, SLC38A1 (SNAT1) and SLC38A2 (SNAT2) can also drive the influx of glutamine into cells (Jin et al., 2023)

Lipid oxidation and oxidative damage to mitochondrial DNA further diminish mitochondrial function, establishing a self-perpetuating vicious cycle to exacerbate mitochondrial dysfunction and oxidative stress [80]

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