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Increased expression of prolyl endopeptidase induced by oxidative stress in nucleus pulposus cells aggravates intervertebral disc degeneration
Furthermore, mitochondrial ROS acts as a second messenger to activate inflammasomes and augment pathogen clearance
Robb and Stuart, 2010
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Behavioral signs of axial low back pain and motor impairment correlate with the severity of intervertebral disc degeneration in a mouse model
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