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Concentrations above start to see increased transepidermal water loss (TEWL) and reduced hydration

The existing evidence base comes from preclinical (animal) studies conducted primarily at Washington State University, where the compound was developed and patented for potential use in Alzheimer's disease

The combination of minoxidil's established vascular and anagen-extension effects with AHK-Cu's support for dermal papilla cells, VEGF upregulation, and anti-apoptotic activity covers more biological ground than either alone

This is followed by proliferation, where new tissue and blood vessels form, and eventually, tissue remodeling occurs, restoring the wound site to its normal structure and function