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Weight reduction can be achieved through dietary and exercise modifications, and both are recommended by the American Heart Association(AHA)/American College of Cardiology (ACC) and European Society of Cardiologys (ESC) current guidelines, due to their lasting impacts on lipid profiles [19, 27, 28]

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A reasonable combination of different treatments may have a significant synergy, especially for patients with intractable diseases or intolerance to monotherapy [8]

Compared to modern GHRH/secretagogue combination therapies like CJC-1295/Ipamorelin, Sermorelin is the older, single-pathway, shorter-half-life option