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24-hour urine copper if any prior serum copper value exceeded 140 g/dL or if the patient reports new gastrointestinal symptoms (nausea, upper abdominal discomfort)

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In MDD, this peripheral-central coupling is likely amplified by BBB dysfunction characterized by increased permeability, neurovascular inflammation, and associations with symptom severity [172, 173] thereby lowering the threshold at which peripheral KP activation translates into central glutamatergic, oxidative, and neuroimmune dysregulation

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training