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The p-value from the paired t-test is actually lower when the TSPD from just the perturbed points are considered, owing to the reduced variance for the estimated difference

Nutr Neurosci 2020;23:139-48

Astragaloside IV protects brain cells from ischemia-reperfusion injury by inhibiting ryanodine receptor expression and reducing the expression of P-Src and P-GRK2