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Patients should have realistic expectations and understand that individual responses vary considerably

Your progress will depend on factors such as your initial weight, dietary habits, level of physical activity, how the medication dose is increased over time, and how closely you follow both medication and lifestyle recommendations

Psychiatric assessment before starting GLP-1 therapy is important, particularly for patients with histories of disordered eating

Maintain 1.2 mg for at least 1 week 1 3

Notably, SIRT1/PGC-1 levels were significantly decreased in the spinal cord of a rat model, causing mitochondrial dysfunction and overproduction of pro-inflammatory cytokines, including IL-1 and TNF-, which sensitize neurons and induce neuropathic pain (Zeng et al