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Thus, understanding transcriptomic and epigenetic regulation in astrocytes could clarify their precise role in neurodegenerative diseases and offer a potential pathway for leveraging their intrinsic heterogeneity to promote neuroprotection and counteract disease progression (Table 1)

Broide, E., Bloch, O., Ben-Yehudah, G., Cantrell, D., Shirin, H., & Rapoport, M

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As a result, if large, they can sometimes be associated with compensatory vocal fatigue or pain with speaking or singing

Mutant SOD1 aggregates more readily when copper is present (Tokuda and Y Furukawa, 2016)