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No completed, published Phase II human trial exists for either route as of mid-2025

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doi: 10.3389/fcell.2021.733908 Received 06 July 2021 Accepted 25 October 2021 Published 11 November 2021 Volume 9 - 2021 Edited by Yi Zhang, First Affiliated Hospital of Zhengzhou University, China Reviewed by Qianyi He, First Affiliated Hospital of Zhengzhou University, China Nao Yan, Wuhan University, China Updates Copyright 2021 Luo, Su, Gong, Liang, Huang, Chen, Wang and Tian

Bhaskaran NA, Jitta SR, Salwa, Cheruku S, Kumar N, Kumar L (2022) Orally delivered solid lipid nanoparticles of irinotecan coupled with chitosan surface modification to treat colon cancer, Preparation, in-vitro and in-vivo evaluations