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The clinical evidence behind them is unusually strong: in large randomized trials, semaglutide produced about 14.9% mean weight loss over 68 weeks and high-dose tirzepatide up to about 20.9% over 72 weeks

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This is an important consideration when evaluating BPC-157s therapeutic potential

Longer uninterrupted dosing is not recommended because receptor sensitivity can diminish without cycling

To a large extent, these changes are also characteristic of metabolic syndrome, which affects approximately 25% of the worlds adult population and is associated with insulin resistance, hypertension, dyslipidemia and obesity, factors that increasingly lead to cognitive impairment and brain atrophy