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Because the geometric mean cost of CPT code 78431 is still within the range for APC 1522, the proposed APC assignment for CPT code 78431 for CY 2026, we are finalizing the proposed APC assignment of CPT code 78431 without modification

The SURMOUNT-5 trial showed that tirzepatide produced 20.2% body weight reduction compared to 13.7% with semaglutide over 72 weeks, a significant gap that suggests tirzepatide may push past the metabolic ceiling where semaglutide stalls

It does mean the question is finally being tested in a way that can generate more useful human data

"By then, you're playing catch-up

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