The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men with Type 2 Diabetes Mellitus and Obesity. Endocrine Abstracts, vol
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Neurotoxicity is apparently dose-dependent (frequent for 250350 mg/m 2 , almost certain if dosage exceeds 500600 mg/m 2 ) [102], although cases of early onset have been described, particularly in patients with neuropathy risk factors [103]
Consistent with this hypothesis, interrogation of our gene expression microarray data sets revealed increased expression of several JNK regulatory genes including the toxicity and JNK inducer TAJ ( TNFRSF19 , 8.33-fold, adjusted P -value 1.25 10 18 , Supplementary Table 1), and JNK target genes including the p53-inducible proteins TP53I3 ( PIG3 , 5.02-fold, adjusted P -value 1.73 10 16 ) and CDKN1A ( p21 , 4.87-fold, adjusted P -value 9.62 10 15 ) in GSTP1 knockdown cells
4eg), we performed protein immunoprecipitation studies and demonstrated that mut-p53 can interact with NRF2 (Fig
