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Weight loss timeline and realistic expectations Setting realistic expectations prevents disappointment and premature discontinuation

[129] , methotrexate-loaded SLNs were prepared to enhance skin penetration and reduce keratinocyte proliferation

Samples were pooled for quality control purposes (Pool QC) and injected at every five samples to monitor instrument performance and correct instrument drift

This gradual titration helps minimise gastrointestinal side effects, which are common with GLP-1 receptor agonists

Our results show pleiotropic anti-inflammatory and antioxidant effects that may mechanistically underlie the cardiovascular, hepatic, and renal protection consistently seen in large-scale cardiovascular outcome studies (45, 46), in addition to their well-established benefits on glycemic control and weight reduction (47, 48)