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Generally, in accordance with the previous findings (Zhang et al., 2008), Sasuclark et al
10.1016/j.ejphar.2017.09.009 104 MaasA
Alternative skin whitening techniques, such as topical creams or lotions, often contain ingredients like hydroquinone, kojic acid, or vitamin C
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This proteasomal inhibiting role can lead to a reduced proteasomal elimination of ubiquinated P-I (phosphorylated-inhibitor kappa), inhibiting nuclear translocation of NF-, suppressing NF-B activation and its consequences of tumor necrosis factor alpha (TNF-), and NO production ( In addition to inhibiting NF-B, riboflavin inhibits the release and expression of High-mobility group protein B1, a nuclear factor involved in sepsis regulation and other immune-mediated conditions with a critical role in sepsis-associated multiple organ failure ( On the other hand, riboflavin has an indirect anti-inflammatory activity through vitamin D metabolism
