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That matters because readers often ask, "If I used it once and didn't see a big difference, does it work?" In cosmetic use, appearance-focused ingredients often reward patience, especially when the goal is a more balanced-looking complexion rather than a quick temporary effect

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Cancer Metastasis Rev 14 : 205217 Maulik G, Kijima T, Ma PC, Ghosh SK, Lin J, Shapiro GI, Schaefer E, Tibaldi E, Johnson BE, Salgia R (2002a) Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer