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The interaction between circulating AGEs and RAGE (receptor for AGEs) will trigger and enhance the pro-inflammatory state, cell toxicity cell and damage Figure 1 [40]
[9] Protein kinases appear to play a role in regulating various cellular processes
It is not one newly created peptide
Around 60% reached a consensus that it could be a useful adjuvant in acute bacterial and viral infections and 60% agreed that it has a role in CAP but not in VAP
Any potential applications for pain reduction are highly relevant for OUD populations as they may reduce demand for chronic opioid pain management
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